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Biophysical force regulation in cell migration

Presented by: 
Mingming Wu Cornell University, Cornell University
Date: 
Thursday 14th December 2017 - 15:00 to 16:30
Venue: 
INI Seminar Room 2
Abstract: 
In native states, animal cells are surrounded by either fluid or a biopolymer network. The cell-environment interactions critically regulate cell function, as well as collective cell motion. The key to this interaction is the biophysical forces that cells generate. In this talk, I will focus on experimental studies of single cell force regulation in two biological systems. One is on tumor cell-extracellular matrix interaction, in which we find that matrix mechanics, and fluid flows together regulate single tumor cell shape, motility types and invasiveness. In the case of a group of tumor cells, physical forces determine the formation or dissociation of tumor spheroids. In a second example, we studied how sperm cells swim against fluid flows guided by a hydrodynamic force. Curiously, in both cases, biological matrices/fluids enhance force transmission range and promote cell-cell interaction.



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University of Cambridge Research Councils UK
    Clay Mathematics Institute London Mathematical Society NM Rothschild and Sons