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Development of Cancer Diagnostics using mid-Infrared Imaging including FEL-based SNOM

Presented by: 
Michele Siggel-King University of Liverpool
Wednesday 19th April 2017 -
12:15 to 12:20
INI Seminar Room 1
This talk is an introduction to the pioneering work on cancer research within the group of Prof. Peter Weightman (Department of Physics University of Liverpool) and collaborators. The work is aimed at the development of new ways to spot early signs of cancer and in understanding cancer growth and its interaction with drugs. A particular focus is given to cancers, such as in the lower oesophagus, which are very difficult to detect at an early stage in their development. The project brings together scientists with expertise in physics, biology, chemistry and accelerators, and medical doctors. The infrared region of the spectrum is important because it is a fingerprint region, which can be used to identify specific molecules and cellular features; within this work, it is used as a probe to image cells and tissue including oesophageal, oral, breast, prostate and cervical cancers. A variety of sources of infrared radiation are utilised, including the high intensity infrared free-electron-laser (FEL) on the state-of-the-art particle accelerator at Daresbury Laboratory. Techniques include SNOM, AFM-IR and FTIR, which are complementary and cover a range of spatial resolutions. Image analysis routines are being developed and refined within the groups.

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